Diabetes is a chronic metabolic disorder characterized by persistent hyperglycemia and leading cause of morbidity and mortality all over the world today. The antidiabetic activity of metahnolic root extracts of Clematis triloba (CTRE) in Streptozotocin(STZ) and Streptosotocin-Nicotinamide(STZ-NIC) induced diabetes in rats was investigated. Male, albino Wistar rats were divided into five groups of 5 animals in each group. Diabetes was induced in two models by STZ(55 mg/kg, p.o) and STZ-NIC (55,110 mg/kg, p.o)respectively. CTRE (200 mg/kg,400 mg/kg) was administered to diabetic rats for 21 days. The effect on blood glucose, glycosylated haemoglobin, high density lipoprotein (HDL), triglyceride were studied in diabetic rats. CTRE reduced blood glucose, triglyceride and glycosylated haemoglobin and increased in HDL level significantly (p<0.001) in diabetic rats in a dose-dependent manner after 21 days of treatment period. In present study CTRE showed a significant decrease in blood glucose in STZ and STZ-NIC induced diabetic rats.
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